Therefore we compared the proportions of CD8−CD4−, CD8+(CD4−) and CD4+(CD8−) γδ T cells and CD8−CD161−, CD8+CD161− CD8−CD161+ CD8+CD161+ γδ T cell subsets in patients with LCH (Fig. 4a). Here, CD4 is linked to Langerhans cell histiocytosis.