However, the pattern of Swiprosin-1 expression is regulated by various signaling pathways such as PKC-βI/η in HMC-1 mast cells, PKC-θ and NF-κB in Jurkat T cells, BCR in WEHI231 B cells, RANK-L in osteoclast-like cells and EGF in melanoma B16F10 cells, and PKC-β in glomerular endothelial cells2,6,7,11,12. Here, EFHD2 is linked to melanoma.