The AUC value of age (0.586, P < 0.0001, 95% CI: 0.559–0.613), CRP (0.599, P < 0.0001, 95% CI: 0.571–0.628), and BUN (0.559, P < 0.0001, 95% CI: 0.531–0.588) were all significant predictors of hyponatremia. This evidence concerns the gene CRP and Hyponatremia.