In multivariate analyses, an older age at admission (OR 1.007, 95% CI 1.002–1.012, p = 0.006), male gender (OR 1.361, 95% CI 1.105–1.675, p = 0.004), and increased CRP levels (OR 1.093, 95% CI 1.060–1.128, P < 0.0001) were independent risk factors for the development of hyponatremia. The gene discussed is CRP; the disease is Hyponatremia.