TEK and colorectal cancer: Here, in colorectal cancer, network (Fig. 2) and biomarker data (Supplementary Figure 1 and Table 2) revealed that bevacizumab induced correlations between Ang2, Tie2, and Ktrans, the imaging parameter most frequently employed in studies of VEGF inhibitors15, which is a composite of endothelial surface area and vascular permeability.