As VEGF-R2 is most likely derived from the endothelial bed reflecting the volume of tumor microvasculature and tumor Ktrans and the Ang/Tie2 axis are biomarkers that reflect the sensitivity of the tumor to VEGF inhibitors, the implication is that the worst prognostic group bears tumors that achieve angiogenesis through a non-VEGF dependent pathway. This evidence concerns the gene VEGFA and neoplasm.