Taking the same cluster-defined populations, we plotted the trajectories of tumor Ktrans (Fig. 3b, p = 0.003, Mann–Whitney U test) and CK18 (Fig. 3c, p = 0.18, Mann–Whitney U test) showing that the cluster-defined behavior of Tie2 (Fig. 3a) closely resembled tumor Ktrans (Fig. 3b) but not that of CK18 (Fig. 3c). Here, TEK is linked to neoplasm.