In our experiment on mice subjected to partial ligation of mouse carotid artery, Slc2a1 transduction to the endothelium with intact Prkaa1 increased the size of atherosclerotic plaques in mouse carotid arteries, indicating that hyper-glycolysis-induced excessive proliferation may trigger permeability and consequently accelerate atherosclerosis. The gene discussed is PRKAA1; the disease is atherosclerosis.