Administration of phloridzin at a dose of 50 mg/kg p.o. daily slightly counteracted some effects of diabetes on the serum biochemical parameters in HFD/STZ rats (LDL cholesterol and osteocalcin concentrations were not statistically different from the healthy controls any more, and the HDL/LDL cholesterol ratio increased in relation to the diabetic control rats and returned to the normal values; furthermore, the uric acid concentration normalized). The gene discussed is BGLAP; the disease is diabetes mellitus.