APC and cancer: Thus, methylation levels of seven gene promoters [Adenomatosis polyposis coli (APC), BRCA1, DNA repair associated (BRCA1), Cyclin D2 (CCND2), Fork-head box A1 (FOXA1), Phosphoserine Aminotransferase 1 (PSAT1), Ras association domain family 1 isoform A (RASSF1A) and Secretoglobin family 3A member 1 (SCGB3A1)] previously reported as dysregulated in BrC and conveying diagnostic and/or prognostic information [7,8,9,14,29] were firstly assessed in tissue for confirmation of cancer-specificity and prognostic significance.