Co-culture of BMSCs from MM patients with MM cell lines resulted in an increase of survivin that contributes to daunorubicin resistance in MM cells; and the resistance could be reversed by blocking survivin, which would decrease resistance to daunorubicin, melphalan, and dexamethasone agents, and inhibit the growth of MM cells [97,98]. The gene discussed is BIRC5; the disease is Miyoshi myopathy.