Thus, induction of β1-integrin, which causes VLA-4-mediated CAM-DR in MM, is characterized by G1 cell cycle arrest accompanied by an increase of expression in CDK inhibitors, p21Cip1/Waf1 and p27Kip1 [87], and a decrease in Bim (an apoptotic BCL-2 family) [94] and Cyclin A and Cyclin E activity [87]. Here, BCL2 is linked to Miyoshi myopathy.