Moreover, the interaction between macrophages and MM cells via P-selectin glycoprotein ligand-1 (PSGL1)/selectin and ICAM-1/CD18 activate extracellular signal–regulated kinase 1/2 (ErK1/2) and c-myc pathways and confer drug resistance in MM [114]. The gene discussed is MAPK3; the disease is Miyoshi myopathy.