On examination during the years 2016–2017, he was categorized at stage 2.5 of the modified Hoehn and Yahr Scale, with a United Parkinson's Disease Rating Scale (UPDRS) score of 41/199 (electronic supplementary material, table S1) Dopamine transporter (DaT) single-photon emission computerized tomography (SPECT) of the brain demonstrated reduced density of DA synaptic terminals in the caudate and putamen consistent with degenerative PD (figure 5a). The gene discussed is SLC6A3; the disease is Parkinson disease.