Using immunodetection, we have re-tested the plasma expression of protein candidates belonging to the regulated pathways identified by plasma TMT proteomic analysis in ALS patients and in SOD1G93A transgenic mice, including metabolic processes (APOE, APOA1), acute response, inflammation and cell senescence (ITGB3, Galectin-3, TGFB1). Here, LGALS3 is linked to amyotrophic lateral sclerosis.