RHO and amyotrophic lateral sclerosis: Chaperonin mediated protein folding and mitotic processes (pre-symptomatic mouse model, early and late human ALS; Fig. 4a); RHO GTPase activators of IQGAPs (symptomatic mouse model, late human ALS) and apoptosis, anchoring of the basal body to the plasma membrane and AURKA Activation by TPX2 (symptomatic mouse model, early human ALS) (Fig. 4c) were among the pathways shared by human and mouse ALS.