ITGB3 and amyotrophic lateral sclerosis: There was no statistically significant regulation of Galectine-3, TGFb1, ApoA1 and ITGB3 plasma levels at group analysis comparing healthy controls to ALS-FAST and ALS-Slow in both discovery and re-test cohorts, although a trend of up-regulation in ALS-Fast compared to ALS-Slow was seen in both cohorts for these protein candidates (data not shown).