Using immunodetection, we have re-tested the plasma expression of protein candidates belonging to the regulated pathways identified by plasma TMT proteomic analysis in ALS patients and in SOD1G93A transgenic mice, including metabolic processes (APOE, APOA1), acute response, inflammation and cell senescence (ITGB3, Galectin-3, TGFB1). The gene discussed is APOE; the disease is amyotrophic lateral sclerosis.