Kaplan Mayer analysis identified reduced survival in the higher APOE tertile compared to middle and lower tertiles (p = 0.0156; Fig. 5a2) while evaluation of diagnostic performance by receiver operating characteristic (ROC) analysis showed that APOE levels separated ALS-Fast from ALS-Slow (Area: 0.6759; Std. Here, APOE is linked to amyotrophic lateral sclerosis.