As MTs play a critical role in the movement of vesicles, mitochondria and other cellular constituents within neurons via axonal transport [21], it is likely that the dissociation of tau from MTs in tauopathies alters both MT structure and axonal transport, although the observation of axonal transport deficits in other neurodegenerative diseases with neuronal protein inclusions (e.g., Parkinson’s disease and amyotrophic lateral sclerosis) suggests that inclusions themselves may affect MT structure and/or function [22]. Here, MAPT is linked to neurodegenerative disease.