Our study provides an exciting opportunity to advance our knowledge of the effects of IDH1 mutation and 2-HG accumulation to identify several mechanisms which can help to understand the Janus-faced role of IDH1 mutations in the progression of gliomas – IDH mutations could be driver oncogenic alterations, however, IDH-mutant human gliomas have better prognosis than wild-type. The gene discussed is IDH1; the disease is central nervous system cancer.