TARDBP and neuropathy: Our results suggest that Znf179-mediated TDP-43 polyubiquitination not only regulates the normal routes of TDP-43 degradation via the UPS, but also reduces insoluble TDP-43 aggregates by stimulating autophagic clearance routes, implying a critical role for Znf179 E3 ligase in attenuating TDP-43-related neuropathy.