Microarray data (Gene Expression Omnibus; GEO) revealed that Znf179 is significantly downregulated in mouse models of neurodegenerative diseases such as Huntington’s disease (GEO: GDS717) and ALS (GEO: GSE10953) (Additional file 1: Figure S1), implying that Znf179 is associated with neurodegenerative pathology [26, 27]. Here, RNF112 is linked to amyotrophic lateral sclerosis.