Notably, the turnover rates and insoluble aggregates clearance of TDP-43 are regulated by Znf179 and the knockout of Znf179 in mice significantly increases the insoluble TDP-43 aggregates and punctate staining of TDP-43 inclusions in brain, suggesting that the E3 ligase, Znf179, is highly correlated with TDP-43-UBI (+) neuropathy. The gene discussed is TARDBP; the disease is neuropathy.