TARDBP and amyotrophic lateral sclerosis: The excess amount of TDP-43 in FTLD/ALS patients’ brain has a propensity to form insoluble TDP-43 deposits, since TDP-43 proteins is intrinsically an aggregation prone protein [41], which can be observed in the form of polyubiquitinated and truncated 35 kDa/25 kDa TDP-43 fragments in urea fraction [6, 13].