Ying et al. [84] studied the effect of hepatocyte growth factor (HGF) of cancer-associated fibroblasts (CAF) on the Met/PI3K/AKT activation, GRP78 expression on the human non-small cell lung cancer A549 cells cultured in the 3D matrix in the presence of an anticancer drug (paclitaxel). Here, HSPA5 is linked to cancer.