More recently, Balsat et al. reported on MRD evaluation in 152 NPM1-mutated AML patients, showing that patients who did not achieve a 4-log reduction in NPM1-mutated transcripts in PB samples after induction therapy (45% of study cohort) had a higher 3-year CIR (65.8% versus 20.5%) and a shorter 3-year OS (40.8% versus 91.2%) compared with patients who obtained an adequate MRD reduction [57]. Here, NPM1 is linked to acute myeloid leukemia.