NPM1 and acute myeloid leukemia: Moreover, Sockel et al. pre-emptively treated with 5-azacitidine 10 NPM1-mutated AML patients in first or second CR after intensive chemotherapy or autologous or allogeneic HSCT (3 cases), who experienced either molecular relapse or persistently detectable MRD positivity in sequential RQ-PCR analyses [82].