EGFR and non-small cell lung carcinoma: Furthermore, the investigators also reported that inhibition of NF-κB signaling could cause TKI sensitivity in EGFR-mutant NSCLC cells and that upregulated NF-κB signaling condition was relative to worse PFS and decreased OS in EGFR-active mutant NSCLC in patients treated with EGFR-TKIs [130].