In colorectal cancer, epidermal growth factor receptor (EGFR) ligand aberrations, with amphiregulin, epiregulin and transforming growth factor (TGF)-α may act as prognostic indicators and predictive biomarkers of the response to anti-EGFR antibodies, such as cetuximab or panitumumab, even when wild-type KRAS is present. Here, EGFR is linked to colorectal cancer.