RB1 and lung cancer: Table 5 lists the top 13 KEGG pathways enriched by the 431 mRNAs that were differentially expressed according to EGFR status, providing an idea of which pathways were significantly enriched in EGFR-mutated tumors. Highly enriched pathways included “pathways in cancer” (p = 4.07E–03), “Wnt signaling pathway” (p = 4.30E–02), “small-cell lung cancer” (p = 4.88E–02), and “non-small-cell lung cancer” (p = 4.17E–02). The “nonsmall-cell lung cancer” pathway was enriched by mRNAs, including EGFR, RB1, and CDK6, all known to be associated with tumorigenesis in NSCLC [3,42,44].