Quantification of the gene expression of protein kinase AMP-activated catalytic subunit α 1 (AMPK) showed a significant increase in this transcription factor for diabetic animals and periodontal disease treated with PLGA + 10 mg/kg Met when compared to the positive control and PLGA + 100 mg/kg Met (p < 0.05) groups, Figure 5. Here, PRKAA2 is linked to periodontal disorder.