In line with this, AMPK activation inhibits CFTR in Madin-Darby canine kidney (MDCK) cells [165] as well as decreases cystogenesis in murine models of ADPKD [165,166], suggesting a potential role for pharmacological AMPK activation in the treatment of ADPKD [165,166]. The gene discussed is PRKAA2; the disease is autosomal dominant polycystic kidney disease.