YAP1 and pancreatic neoplasm: Furthermore, we observed a clear correlation between CAV1 expression and YAP nuclear localization in human cancer-associated fibroblasts (CAFs) from pancreatic tumors (Figures 5C and 5D), and CAV1 silencing in these cells induced YAP cytosolic retention (Figure 5D), supporting a major role for a CAV1-YAP regulation in determining the activation state of stromal cell populations in vivo.