We chose pancreatitis as a model to study the potential contribution of CAV1-YAP regulation in vivo, because YAP is required for pancreatitis-induced ADM (Morvaridi et al., 2015) and CAV1 expression is upregulated in pancreatic cancer and it is associated with decreased survival (Chatterjee et al., 2015). The gene discussed is YAP1; the disease is familial pancreatic carcinoma.