We chose pancreatitis as a model to study the potential contribution of CAV1-YAP regulation in vivo, because YAP is required for pancreatitis-induced ADM (Morvaridi et al., 2015) and CAV1 expression is upregulated in pancreatic cancer and it is associated with decreased survival (Chatterjee et al., 2015). This evidence concerns the gene YAP1 and pancreatitis.