SOST and type 2 diabetes mellitus: Strengths of our study comprises the evaluation of serum SOST and irisin levels in Egyptian T2DM+ATHR patients for the first time while focusing on the female population who are at greater risk and the examination of the presence of a correlation between the two markers and their sensitivity/specificity using ROC curve analysis as fundamental tools to evaluate their usefulness as novel reliable diagnostic and/or prognostic markers for the disease progression.