AIRE and rheumatoid arthritis: The association between several SNPs (rs2075876, rs760426, rs1800250, rs2776377, rs1055311, rs933150, rs1003854, rs2256817, rs374696, rs1078480) of the AIRE gene and RA risk was studied before, and a recent meta-analysis (22) proved that rs2075876 and rs760426 are significantly associated with an increased risk of RA.