Transcription factors c‐Myc functions as an essential oncogene in numerous cancers.13 c‐Myc could associate with myc‐associated factor X (MAX) to form heterodimer, which binds to E‐box (5′‐CACGTG‐3′) in the promoter of LDHA, thus transactivating LDHA expression.14 In pancreatic cancer, c‐Myc expression was positively related to LDHA, and knockdown of c‐Myc could inhibit LDHA expression, impairing lactate production and glucose consumption.15 Intriguingly, Zhang et al16 found that inhibition of LDHA increased c‐Myc expression, suggesting that LDHA had a negative feedback on c‐Myc expression. The gene discussed is MYC; the disease is cancer.