The expression of LDHA was positively correlated with 5‐fluorouracil resistance; LDHA could be suppressed by introduction of miR‐34a, which could restore the sensitivity of advanced colon cancer to 5‐fluorouracil.44 Besides, miR‐34a could indirectly inhibit LDHA expression by regulating cytokines.45 Thus, these miRNAs play a significant part in negative regulation of LDHA via posttranscriptional modification. The gene discussed is LDHA; the disease is malignant colon neoplasm.