LDHA and melanoma: Gossypol, a natural phenol derived from cotton plants, inhibits LDHA by competing with NADH.112 Gossypol showed dose‐dependent cytotoxic activity in diverse cancer cells, including melanoma (SK‐mel‐19, SK‐mel‐28), small‐cell lung cancer (H69), breast cancer (Walker), cervical cancer (Sihas), myelogenous leukemia (K562), and glioma (HS683, U373, U87, and U138).113, 114 Meanwhile, gossypol shows satisfactory anticancer efficiency in vivo.