SIRT2 and pancreatic neoplasm: In human pancreatic cancer, a decrease in acetylated levels of LDHA K5 leads to activation of LDHA enzyme activity and inhibition of LDHA degradation.49 Zhao et al50 showed that in pancreatic cancer LDHA could be deacetylated at K5 by the deacetylase sirtuin 2 (SIRT2).