Chesnelong et al found glioma with mutant isocitrate dehydrogenase (IDH) had a low‐level LDHA compared with IDH wild‐type, and the molecular underpinning might be that mutant IDH causes higher methylation in LDHA promoter.11 Besides, Maekawa et al reported retinoblastoma cell line NCC‐RbC‐51 hardly express LDHA, which, however, would be restored by demethylating agent 5‐aza‐2′‐deoxycytidine.12 These all suggest that methylation modification plays a vital part in LDHA activation mechanisms. The gene discussed is LDHA; the disease is central nervous system cancer.