Brand et al84 found that high expression of LDHA in melanoma resulted in accumulation of lactic acid, and the acidic environment downregulated nuclear factor of activated T cells (NFAT) in T and NK cells, which in turn led to a decrease in IFN‐γ production and attenuated the function of tumor‐infiltrating T cells and NK cells, triggering tumor immunosuppression. This evidence concerns the gene LDHA and melanoma.