LDHA and neoplasm: However, LDHA expression in cancer tissues is not completely consistent with serum LDH levels, which may indicate that tumor LDHA expression and serum LDH levels are two independent predictors of tumors.102 Koukourakis et al62 found that patients with low levels of LDHA in tumor tissues often had low levels of serum LDH, but only 29% of patients with high LDHA expression had elevated serum LDH levels, and 71% of patients with high LDHA expression levels showed normal serum levels.