As is shown above, numerous tumors exhibit high LDHA expression, which contributes to malignant bio‐characteristics.103, 104, 105 Silencing LDHA expression in tumor models inhibits cell proliferation, migration, and tumor growth.51, 59, 72, 106 However, it is rarely harmful to normal cells.57, 107 Additionally, individuals lacking LDHA subunits only develop muscle rigidity and sudden myoglobinuria after strenuous exercise.108, 109 So, high anticancer efficacy along with safe therapeutic window enables LDHA to be a potential antitumor target. This evidence concerns the gene LDHA and neoplasm.