In addition, the staining intensity of LDHA was found to be highly correlated with the histological type and lymph node metastasis of lung cancer, indicating that the tissue level of LDHA had prognostic value in NSCLC.101 Up‐regulation of LDHA levels in tumor tissues can be observed in pancreatic cancer and esophageal squamous cell carcinoma (ESCC), which was associated with metastasis, tumor stage, tumor recurrence, and patient survival.25, 51. This evidence concerns the gene LDHA and familial pancreatic carcinoma.