One immunohistochemistry study, performed to localize PAI‐1 in the CNS, found a positive immunostaining not only in astrocytes but also in rat and human neurons, with greater neuronal expression in the presence of inflammatory processes51, 52 which are common in the brain of AD patients.53 Furthermore, it has been shown that direct injection of Aβ into brain regions may cause an increase of PAI‐1. This evidence concerns the gene SERPINE1 and Alzheimer disease.