In another in vitro study, it was shown that PAI‐1 inhibitors are able to reduce pro‐BDNF levels in hippocampal slices from epileptic mice.118 These data suggest that the compounds targeting tPA/PAI‐1 pathway, such as PAI‐1 inhibitors, may represent a new strategy to modulate brain BDNF expression in pathological conditions, including AD. Here, SERPINE1 is linked to Alzheimer disease.