INS and cancer: Any disruption of phospholipid metabolism could result in an undermining of cell membrane integrity, eventually causing cell function loss and cell death.32, 33 Although the exact regulatory mechanisms that govern phospholipid metabolism are still unclear, drugs targeted to phospholipids have shown great promise in cancer treatment.34, 35, 36, 37 In the case of insulin sensitivity, phospholipid alterations are known to be associated with insulin resistance.