Weakened autophagy has also been postulated to be involved in the origins of several neurodegenerative diseases, such as AD, PD, HD, amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), being responsible for β-amyloid/tau, α-synuclein, or mHtt clearance [37]. The gene discussed is MAPT; the disease is neurodegenerative disease.