Clinical evaluation of component-specific diagnostic work-up in Central and South European (Spanish) patients with cherry allergy; diagnosis partially confirmed by controlled oral provocation, additional cohorts with pollen allergy and non-atopics; heterogeneous sensitization profiles depending on the region investigated and clear advantage of single allergens over extract-based diagnostic work-up (prick test; specific IgE with cherry extracts). The gene discussed is IGHE; the disease is seasonal allergic rhinitis.