IGHE and allergic disease: IgE against alpha-Gal can be found in patients with allergies against offal and mammal meat [35] and can be determined by new laboratory reagents (laboratory number Ro307, art number 14-4997-10, ThermoFisher, Freiburg, Germany) and an immunoblot test (laboratory U. Jappe, Research Group for Clinical and Molecular Allergy, Research Center Borstel, Germany).