In an international cohort study investigating 2,184 children, it was be demonstrated that high specific IgE titers (i.e., “high-risk” IgE titers, defined according to the specific food) against cow’s milk, hen’s egg, and/or peanut were most frequently observed in infants in whom eczema had manifested before the end of their 3rd month of life [17]. The gene discussed is IGHE; the disease is Eczematoid dermatitis.