Over the last decade, TNIP1 has been reported among the highest scoring non-MHC genes across multiple genome-wide association studies (GWAS), spanning multiple populations and diseases including psoriatic arthritis [13–16], systemic sclerosis [17, 18], systemic lupus erythematosus [19–24], and psoriasis [25–27]. The gene discussed is TNIP1; the disease is systemic sclerosis.