GSK3B and diabetes mellitus: Mokhtari et al. [26] confirmed that at the 10th week of diabetes induction, phosphorylation of GSK-3β in the DM-I/R group was significantly less than the I/R group, suggesting that diabetes impairs the intracellular signaling pathways and increases cardiac injury as compared to normal hearts; however, no significant difference was seen between I/R and DM-I/R groups in our study.