MAPK3 and ischemia: Previous studies had demonstrated that the Reperfusion Injury Salvage Kinase (RISK) pathway including Phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) and extracellular signal-regulated kinase 1/2 (ERK1/2) were activated to possess protective effects at the onset of myocardial reperfusion followed by ischemia.