However, the aforementioned index in the DM-S group was similar to the S group, and no significant difference was observed between DM-S and S groups, indicating that a 4-week diabetic state may not significantly influence cardiac function, which was consistent with a previous study [25], while Mokhtari et al. reported that STZ-induced diabetes at the 10th week significantly increases the level of cTnI and exacerbates the myocardial injury [26]. This evidence concerns the gene TNNI3 and diabetes mellitus.