Under this assumption a recent study conducted by Kelley et al. which integrated ChIP-seq and RNA-seq data obtained from patient-derived xenografts from head and neck squamous cell carcinoma (HNSCC) samples showed that H3K4me3 and H3K27ac histone marks are associated with tumor-specific transcriptional changes in their target genes including EGFR, FGFR1, and FOXA1 [36]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.