As shown in Table 3, univariate regression analysis between lipid profile and all circulating markers and aggregability parameters of all patients at baseline revealed that LDL-cholesterol levels are (i) positively associated with IFN-γ, IL-6, VEGF, E-selectin, and sCD-40L as circulating markers of inflammation, endothelial dysfunction, and in vivo platelet activation, respectively, 8-OH-dG as marker of oxidative stress, platelet aggregation to ADP, collagen, AA, and IC-50 L-ASA and (ii) inversely associated with the anti-inflammatory markers IL-10 and sRAGE. This evidence concerns the gene CD40LG and endothelial dysfunction.