AGER and isolated hemihyperplasia: Furthermore, by using NF-κB siRNA to downregulate NF-κB (Figures 1(g) and 1(h)), it was observed that NF-κB siRNA was able to significantly reduce the upregulation of RAGE expression that resulted from IH (Figures 1(g) and 1(i)), which suggested that NF-κB signalling played a positive role in the activation of RAGE in IH.