LMNA and laminopathy: LMNA mutations cause laminopathies, a spectrum of multisystem diseases, including some types of muscular dystrophy, lipodystrophy and acrogeria syndromes.1 They also cause lamin heart disease,2 which accounts for up to 10% of dilated cardiomyopathies (DCM).3 Although there is significant pleiotropy of phenotypic expression in lamin heart disease,2 4 broadly it causes a malignant type of DCM with heart failure characterised by ventricular arrhythmias (VAs), cardiac conduction system disease (CCD) and an untreated sudden cardiac death (SCD) rate as high as 46%.5