LMNA and heart disorder: Possibly as a result of lethality, we found that no cardiac disease-causing LMNA mutation has been reported affecting the (1) NLS (a.a. 417–422); (2) Ser 625 potential phosphorylation site; or (3) the lamin A specific –CaaX motif (a.a. 661–664; see figure 2), while only one mutation has been detected in the unique lamin C C-terminal sequence (VSGSRR, a.a. 566_572, NM_005572.3).