INS and diabetes mellitus: Additionally, it has been reported that miR-26a regulates genes involved in fatty acid, cholesterol metabolism and insulin signaling such as ACSL3, ACSL4, PKCδ, PKCθ, GSK3β, and SERBF1, showing its crucial role in preventing the development of type 2 diabetes mellitus, as some of those genes are direct targets for miR-26a and others are downstream of its target genes [24].