IL1B and neurodegenerative disease: Neurodegenerative diseases are characterized by progressive neuronal loss and impaired neuronal function, along with activation of microglia and astrocytes and increased release of a range of proinflammatory cytokines such as TNF-α, IL-6, IL-1β, and IFN-γ and oxidative factors such as ROS, NOS, and PGE2 [5, 15, 18].