MAPT and Alzheimer disease: For example, in transgenic mice with AD, curcumin effectively counteracts p25-mediated glial activation and proinflammatory chemokine/cytokine production [10], reduces oxidative damage such as amyloid plaque burden and preformed Aβ fibrils, and reverses progression of tau/amyloid pathology, along with amelioration of cognitive impairments [77].