A positive association was observed between serum copeptin and total stroke (ORrude = 1.45, 95% CI: 0.78–2.69 for tertile 3 vs. tertile 1; ORadjusted = 1.23, 95% CI: 0.62–2.44 for tertile 3 vs. tertile 1); however, no statistical significance was found for this increasing trend (Ptrend = 0.052). Here, AVP is linked to Stroke.