When exposed Ishikawa cells to FSH and LY294002, LY294002 reduced the tumor cell viability, increased cell apoptosis rate and proapoptosis Bax protein expression, decreased the anti-apoptosis Bcl-2 protein expression and the tumor cell migration ability, downregulated the levels of p-AKT/Akt, FSHR, Gankyrin, and cyclinD1 proteins expression, and upregulated the levels of HIF-α. The gene discussed is AKT1; the disease is neoplasm.