AKT1 and Insulin resistance: Although many evidence indicates that activation of phosphatidylinositol 3-kinase (PI3K)/AKT pathway is associated with marked accumulation of intracellular lipid droplets and promotion from NASH to fibrosis [42, 43], some studies revealed that PI3K/Akt activation is benefit for ameliorating insulin resistance [44], oxidative stress [45], and lipid accumulation [46].