As shown in Figure 4, the expression of LOX-1 in the aortic root was dramatically (P<0.001) attenuated by LHRD treatment (400 mg/kg/d) compared with vehicle treatment control in ApoE−/− mice, indicating that LHRD ameliorates atherosclerosis through downregulation of LOX-1. This evidence concerns the gene APOE and atherosclerosis.