Resveratrol has also been shown to significantly reduce histopathological grade, as well as the expression of matrix metalloproteinases-2 (MMP-2), matrix metalloproteinases-9 (MMP-9), and VEGF in a rat model of endometriosis; this drug also reduced levels of interleukin-6 (IL-6), IL-8, and TNF-ɑ levels in plasma and peritoneal fluid [80]. This evidence concerns the gene CXCL8 and endometriosis.