Over the last four years, the possible mechanisms of action and effects of irisin in the nervous system have been investigated; an instance is the study on rodents by Li et al. who report that irisin is possibly responsible for the neuroprotection of physical exercise for diseases such as cerebral ischemia, through the activation of ERK1/2 and Akt pathways in brain tissue, as well as protection against brain damage once administered [66]. Here, FNDC5 is linked to brain ischemia.