FNDC5 and neoplasm: Conversely, Gannon et al. revealed the ability of irisin to decrease the number of malignant mammary cells through the induction of apoptosis, in addition to decreasing the viability and migration of these cells, and irisin sensitizes malignant mammary cells for chemotherapeutic treatments such as doxorubicin while decreasing drug uptake, without altering nonmalignant cells; therefore, it could be useful in the adjuvant treatment of some neoplasias [54].