Cancer cells promote angiogenesis early in tumorigenesis, which is driven by an oncogene to express proangiogenic proteins such as the vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), IL-8, placenta-like growth factor (PLGF), and transforming growth factor- (TGF-) β. [85]. The gene discussed is FGF2; the disease is cancer.