AFP and neoplasm: Currently, a minimum survival probability between 50% and 60% at 5 years after LT is demanded in order to balance benefit and harm of LT beyond standard criteria, with microvascular invasion (MVI) [9, 10] and low tumor differentiation that are recognized as most important prognostic factors, together with serum levels of alphafetoprotein (AFP) and response to neoadjuvant locoregional tumor treatment (LRTT) [11, 12].