We previously demonstrated that E-cadherin membrane expression—a hallmark of the epithelial reversion that mark dormant micrometastatic tumor cells—was both a marker and mechanism of resistance to statin-mediated growth inhibition.27 Herein, we show that atorvastatin can directly suppress growth of tumor cells in in vitro, ex vivo, and in vivo models of breast cancer metastasis. This evidence concerns the gene CDH1 and neoplasm.