Inhibition of PI3K or Mek1/2 did not significantly influence total nuclei number (Fig. 4b) or tumor burden (Fig. 4c) as compared to atorvastatin treatment alone, but PI3K inhibition potentiated atorvastatin-mediated suppression of MDA-MB-231 proliferation in a dose-dependent manner (p-value  = 0.01) (Fig. 4d, e). This evidence concerns the gene MAP2K1 and neoplasm.