We previously demonstrated that membrane E-cadherin was a marker and mechanism of resistance to atorvastatin treatment, whereas vimentin did not correlate with atorvastatin resistance.27 Herein in breast cancer cells, we found the mesenchymal MDA-MB-231 cells were more sensitive to atorvastatin-mediated growth suppression than the epithelial MCF-7 cells (Fig. 2a). This evidence concerns the gene CDH1 and breast cancer.