These results show that PFB has important immunomodulatory effects on IL-1β-activated human astrocytes in vitro, which suggests that PFB may have a beneficial effect in the prevention and/or treatment of the neuroinflammatory state associated with such neurodegenerative diseases as Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease, among others152–158. The gene discussed is KRT75; the disease is early-onset autosomal dominant Alzheimer disease.