Previous studies of SOD1-aggregates were restricted to cells that are biochemically very different from MNs such as the neuroblastoma cell line Neuro2A (N2A), the spinal cord-neuroblastoma hybrid cell line NSC-34, the adrenal gland tumor line PC12 and a Chinese hamster ovary (CHO) cell line27,28,31,32. The gene discussed is SOD1; the disease is neuroblastoma.