SOD1 and amyotrophic lateral sclerosis: The SOD1 protein is ubiquitously expressed but, in ALS, it causes specific MN degeneration despite the presence of SOD1 aggregates not only in MNs, but also in the nuclei of ventral horn astrocytes, microglia, and oligodendrocytes of familial ALS, as well as sporadic ALS, patients24.