NDE1 and psychiatric disorder: Recently, Bradshaw et al. [25], using gene expression and psychoactive medication data, have elegantly demonstrated that the NDE1 SNP rs2242549 associates with significant changes in gene expression and that a significant number of these were predicted targets of miR-484, located within a non-coding exon of NDE1. This has led to the hypothesis that variation at the NDE1 locus may alter risk of mental illness, in part through modification of miR-484, highlighting this as a potentially important locus in targeting treatment [25].