Two gene sets linked to promotion of Wnt signaling were also significantly enriched in only asthmatic horses: “Deletions in the axin genes in hepatocellular carcinoma result in elevated wnt signalling” (FDR = 2.10E−03; REACT_264286.1) and “Axin mutants destabilize the destruction complex, activating Wnt signaling” (FDR = 2.57E−03; REACT_264496.1) (Suppl. The gene discussed is AXIN1; the disease is hepatocellular carcinoma.