Patients in the chronic and accelerated phases of CML associated with both PB and BM basophil percentages of ≥40% [6,7,8,9], patients with autoinflammatory diseases manifesting with recurrent attacks of fever and abdominal pain [27] and additionaly, chronic myeloproliferative disorders [28], mastocytosis variants [29], Castleman’s disease [30] and the possibility of underlying CBL [4,5] should be considered in the differential diagnosis in the patients presented with progressive leukocytosis associated with eosinophilia and elevations in IL-6 and CRP levels. This evidence concerns the gene CRP and chronic myelogenous leukemia, BCR-ABL1 positive.